Medical
Fatemeh Shamakhte; Elaha Tajbakhsh; Hassan Momtaz
Abstract
Methicillin-resistant S. aureus (MRSA) strains circulating among populations and crossing borders constitute a major problem for health control and require a fast and simple genotypic approach. The objective of this study was to determine the prevalence, molecular types and drug resistance pattern of ...
Read More
Methicillin-resistant S. aureus (MRSA) strains circulating among populations and crossing borders constitute a major problem for health control and require a fast and simple genotypic approach. The objective of this study was to determine the prevalence, molecular types and drug resistance pattern of S. aureus isolated from Hospitalized Patients in teaching Hospitals of Ahvaz. this cross-sectional study was from April to September 2023, MRSA strains were identified by phenotypic and molecular methods. The antibiotics studied were), Cefoxitin (15 μg) Gentamicin (10 μg), Ciprofloxacin (5 μg), Erythromycin (15 μg), Clindamycin (2 μg), linzolide(10μg), azithromycin(5 μg). The tests were performed according to the guidelines of clinical and Laboratory Standards Institute (CLSI). It also detected the mecA gene of Methicillin-resistant S. aureus strains (MRSA). 470 Staphylococcus aureus samples from patients hospitalized in different departments of Ahvaz Hospitals included 283 blood culture samples, 75 wound samples, 72 body fluid samples and 40 catheter samples, and 321 (68.3%) MRSA isolates were reported. All these 321 MRSA isolates were tested with ampicillin, ciprofloxacin, clindamycin, linezolid, gentamicin, erythromycin, and azithromycin antibiotics. Also, the results of molecular identification of the mec A gene in 321 strains of S. aureus showed that 312 strains carry the mec A gene. The high prevalence of S. aureus samples can be caused by long-term hospitalization of patients in the ward and excessive use of antibiotics to treat the infection and increased resistance in isolates. As a result, more monitoring of the hospital's infection control department, as well as the expansion of the correct use of antibiotics, seems necessary and important.
Medical
Fatemeh Shamakhteh; Suhaib Khalid Ibrahim; Morteza Saki; Sahar Taha Hatif
Abstract
One of the most significant harmful microorganisms is Staphylococcus aureus. Due to the rise in the resistance of this bacteria to antibiotics and the lengthening of hospitalized patients' treatments, one of the causes of infection and mortality among patients hospitalized in special care units of hospitals. ...
Read More
One of the most significant harmful microorganisms is Staphylococcus aureus. Due to the rise in the resistance of this bacteria to antibiotics and the lengthening of hospitalized patients' treatments, one of the causes of infection and mortality among patients hospitalized in special care units of hospitals. In this cross-sectional descriptive study, samples of 113 S. aureus isolates were taken from patients who had spent 4 months in the special care units of Ahvaz teaching hospitals. These samples were then tested using antibiograms for oxacillin, cefoxitin, linezolid, ciprofloxacin, clindamycin, trimethoprim sulfamethoxazole, vancomycin, penicillin, and Antibiotic resistance was discovered, and the findings were evaluated against those of previous investigations. 51 (57.63%) of the 113 patient-isolated samples were female, while 62 (70.1%) were male. The oldest person was 89 years old and the youngest was 4 years old. Linezolid antibiotics were effective against every tested strain, although they were ineffective against 6 tested strains (6.31%), 4 tested strains (3.54%), and 1 tested strain (88%) isolated from wound urine. Vancomycin-resistant bacteria have been found. The findings of this study demonstrate that hospital strains of S. aureus are resistant to many antibiotics. Therefore, it is important to avoid prescribing and using available antibiotics unnecessarily. It is also advised to look at the evolution of antibiotic resistance in hospital infection management in order to stop the development of resistance to these antibiotics.
)
)